Effect of white lion goose serum on gastric cancer cells
DOI:
https://doi.org/10.5327/fst.124822Palavras-chave:
White Lion Goose serum, gastric cancer cells, the apoptosis, the migrationResumo
Goose blood is rich in nutrients and a variety of bioactive ingredients, it have the effect of prevent cancer in humans, but the mechanism is not clear. So, we studied the effects of White Lion Goose serum on gastric cancer cells. The in vitro cell proliferation of human gastric cancer cells (AGS) was analyzed by a CCK-8 assay; cell morphology was observed using an inverted microscope; the wound healing ability of cells was detected by a scratch and abrasion test; and cell cycle distribution and cell apoptosis were detected by flow cytometry. The results showed that with increased concentration and prolonged incubation time, the serum of White Lion Goose reduced the viability, changed the morphology, and reduced the migration rate of gastric cancer cells. The proportion of gastric cancer cells in the early (G0/G1 phase) and late (G2/M phase) stages of DNA synthesis was decreased, the proportion of cells in stationary phase (S phase) was increased, and the apoptosis rate was increased accompanied by a decrease in the number of viable cells. The serum of White Lion Goose had a significant inhibitory effect on the proliferation of human gastric cancer cells, changed the distribution of the cell cycle and induced apoptosis in both a dose- and time-dependent manner. The results showed that the blood of the White Lion Goose contained highly bioactive components, which had an obvious inhibitory effect on the proliferation of gastric cancer cells cultured in vitro.
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Amiri, F., Moradian, F., & Rafiei, A. (2015). Anticancer effect of lactoferrin on gastric cancer cell line AGS. Research in Molecular Medicine, 3(2), 8-13. https://doi.org/10.7508/rmm.2015.02.002
An, Z., He, P., Wang, G., Liu, G., & Jiang, J. (2022). PP-10 induces apoptosis via JNK/SPAK activation and STAT3 inhibition in Hepatocarcinoma cells in vitro. Food and Science Technology, 42, e102921. https://doi.org/10.1590/fst.102921
Bernhard, D., Tinhofer, I., Tonko, M., Hübl, H., Ausserlechner, M. J., Greil, R., Kofler, R., & Csordas, A. (2000). Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Different, 7(9), 834-842. https://doi.org/10.1038/sj.cdd.4400719
Chen, M., Chen, J., Yang, D., Wang, J., Lin, R., Zeng, H. (2011). Development of goose blood paste. Food Research and Development, 32(7), 72-75.
Deswaerte, V., Nguyen, P., West, A., Browning, A. F., Yu, L., Ruwanpura, S. M., Balic, J., Livis, T., Girard, C., Preaudet, A., Oshima, H., Fung, K. Y., Tye, H., Najdovska, M., Ernst, M., Oshima, M., Gabay, C., Putoczki, T., & Jenkins, B. J. (2018). Inflammasome adaptor asc suppresses apoptosis of gastric cancer cells by an il18-mediated inflammation-independent mechanism. Cancer Research, 78(5), 1293-1307. https://doi.org/10.1158/0008-5472.CAN-17-1887
Fan, S., Zhang, Y., Zhang, C., & Peng, X. (2006). Anticancer mechanism and drug development of goose blood. China Poultry, 28(6), 53-54. https://doi.org/10.16372/j.issn.1004-6364.2006.06.022
Garaci, E., Pica, F., Serafino, A., Balestrieri, E., Matteucci, C., Moroni, G., Sorrentino, R., Zonfrillo, M., Pierimarchi, P., & Sinibaldi-Vallebona, P. (2012). Thymosin α1 and cancer: action on immune effector and tumor target cells. Annals of the New York Academy of Sciences, 1269(1), 26-33. https://doi.org/10.1111/j.1749-6632.2012.06697.x
Garaci, E., Pica, F., Sinibaldi-Vallebona, P., Pierimarchi, P., Mastino, A., Matteucci, C., & Rasi, G. (2003). Thymosin alpha 1 in combination with cytokines and chemotherapy for the treatment of cancer. International Immunopharmacology, 3(8), 1145-1150. https://doi.org/10.1016/s1567-5769(03)00053-5
Guillem, E. B., & Sampsel, J. W. (2006). Antitumor-associated antigens IgGs: dual positive and negative potential effects for cancer therapy. Advances in Experimental Medicine and Biology, 587, 341-374. https://doi.org/10.1007/978-1-4020-5133-3_26
Jiao, F., Xu, H. Q., Su, X. Y., Xue, Y. Y., & He, Y. H. (2022). Differential value of 18F -FDG PET /CT imaging between gastric lymphoma and gastric cancer. Modern Oncology, 30(17), 3209-3212.
Li, J., Zhang, X., Jia, J., Xie, B., Zhang, C., Wang, H., Li, H., & Ma, J. (2022). CLDN18-ARHGAP26 function in gastric cancer and be a new therapeutic target by ABCG2 and ABCB1 pathway. Food Science and Technology, 42, e54821. https://doi.org/10.1590/fst.54821
Li, M., Yao, R., Huang, N., Liu, Q., & Li, Q. (2014). The amount of goose blood added to goose blood sausage texture and The influence of sensory properties. Food Science and Technology, 39(4), 122-128. https://doi.org/10.13684/j.cnki.spkj.2014.04.027
Li, Q., Teitz-Tennenbaum, S., Donald, E. J., Li, M., & Chang, A. E. (2009). In Vivo Sensitized and In Vitro Activated B Cells Mediate Tumor Regression in Cancer Adoptive Immunotherapy. Journal of Immunology, 183(5), 3195-3203. https://doi.org/10.4049/jimmunol.0803773
Liu, S. L., Shi, D. Y., Pan, X. H., & Shen, Z. H. (2001). Inhibition of Proliferation and Expression of N-ras in Hepatoma Cells by Antioxidation Treatment. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 33(4), 463-466.
Meng, N., Yu, H., Luo, P. F., Zhou, J. Y., Su, J., Fan, X. K., & Wu, M. (2022). Trend analysis of disease burden of stomach cancer in Jiangsu residents from 1990 to 2019. Chronic Disease Prevention and Control in China, 30(9), 644-654. https://doi.org/10.11735/j.issn.1004-0242.2023.03.A004
Millikin, D., Meese, E., Vogesstein, B., Witkowski, C., & Trent, J. (1991). Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. Cancer Research, 51(20), 5449-5453.
Mizukami, M., Hanagiri, T., Shigematsu, Y., Baba, T., Fukuyama, T., Nagata, Y., So, T., Ichiki, Y., Sugaya, M., Yasuda, M., So, T., Takenoyama, M., Sugio, K., & Yasumoto, K. (2005). Effect of IgG produced by tumor-infiltrating B lymphocytes of lung cancer on growth of tumor xenotransplanted into SCID mice. Anticancer Research, 26(3A), 1827-1831.
Peng, Y. Q., Shi, J. H., Ding, H., He, Y., & Zhao, M. (2017). Review on the treatment for digestive tract cancer using goose blood. Shandong Zhongyi Zazhi, 2, 103-105.
Qi, Y., Li, X. M., & Xu, C. Y. (2017). Clinical value of thromboelastography in evaluating malignancy thrombophilia and the effects on coagulation of chemotherapy. Chinese Journal of Laboratory Diagnosis, 21(4), 592-594.
Russo, A., & Strong, V. E. (2017). Minimally invasive surgery for gastric cancer in USA: current status and future perspectives. Translational Gastroenterology and Hepatology, 2, 38-44. https://doi.org/10.21037%2Ftgh.2017.03.14
Schulof, R. S., Lloyd, M. J., Cleary, P. A., Palaszynski, S. R., Mai, D. A., Cox, J. W. Jr., Alabaster, O., & Goldstein, A. L (1985). A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancer. Journal of Biological Response Modifiers, 4(2), 147-158.
Storm, L., Christensen, I. J., Jensenius, J. C., Nielsen, H. J., Thiel, S.; Danish Study Group on Early Detection of Colorectal Cancer (2015). Evaluation of complement proteins as screening markers for colorectal cancer. Cancer Immunology and Immunotherapy, 64(1), 41-50. https://doi.org/10.1007/s00262-014-1615-y
Strassburger, M., Bloch, W., Sulyok, S., Schüller, J., Keist, A. F., Schmidt, A., Wenk, J., Peters, T., Wlaschek, M., Lenart, J., Krieg, T., Hafner, M., Kümin, A., Werner, S., Müller, W., Scharffetter-Kochanek, K. (2005). Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radical Biology and Medicine, 38(11), 1458-1470. https://doi.org/10.1016/j.freeradbiomed.2005.02.009
Tian, W. Y., Shen, J. Q., & Chen, W. C. (2017). Suppression of midkine gene promotes the antitumoral effect of cisplatin on human gastric cancer cell line ags in vitro and in vivo via the modulation of notch signaling pathway. Oncology Report, 38(2), 745-754. https://doi.org/10.3892/or.2017.5743
Wang, D. (2017). Effects of immune factors and Cytokines in serum of geese raised in grassland. Chinese Journal of Veterinary Medicine, 37(10), 1939-1943.
Xu, G. Q., Zhang, Y. L., & Yuan, Y. X. (2018). Effect of Goose Blood Composition on the Proliferation of Gastric Cancer Cells and its Protein Spectrometry Identification. Genomics and Applied Biology, 37(8), 3719-3725.
Yang, H. M., Xing, Y., & Zheng, M. Z. (2011). Mechanism of apoptosis induced by resveratrol in human gastric cancer hgc27 cells. Journal of Shanghai Jiaotong University (Med Sci), 31(2), 187-190. https://doi.org/10.3969/j.issn.1674-8115.2011.02.015
Yeh, C. J. G., & Faulk, W. P. (1984). Killing of human tumor cells in culture with adriamycin conjugates of human transferrin. Clinical Immunology and Immunopathology, 32(1), 1-11. https://doi.org/10.1016/0090-1229(84)90037-0
Zhang, M., Wang, J., & Yang, Z. (2022). Immunomodulatory and antitumor activities of the exopolysaccharide produced by potential probiotic Lactobacillus plantarum YW11 in a HT-29 tumor-burdened nude mouse model. Food Science and Technology, 42, e57822. https://doi.org/10.1590/fst.57822
Zhang, X., Fan, G., Zhan, J., & Guan, Z. (2022). SNHG17 promotes gastric cancer cell proliferation and invasion by suppressing RUNX3 via interacting with EZH2. Food Science and Technology, 42, e53521. https://doi.org/10.1590/fst.53521
Zhou, W., Yang, H., & Zhang, L. (2019). Detection and nutrient evaluation of blood bioactive components of 3 species of Northeast geese. China Veterinary Journal, 39(12), 2398-2411. https://doi.org/10.16303/j.cnki.1005-4545.2019.12.21
