Analysis on contamination status and dietary exposure assessment of fumonisins in cereal and oil food samples of a coastal city in northern China
DOI:
https://doi.org/10.5327/fst.03223Palavras-chave:
Cereal and oil food, Fumonisins, Contamination status, Exposure assessmentResumo
Fumonisin is a class 2B carcinogen, which can pollute many food varieties and has been proved to be carcinogenic and teratogenic. 258 pieces cereal and oil food samples were collected from 14 districts in Yantai city from farmers' homes, supermarkets and farmers' markets. The contamination level of fumonisins was detected by High-performance liquid chromatography-tandem mass spectrometry. The pollution level of fumonisin was determined by CODEX STAN 193-1995 and EC No 1881/2006. We conducted quantitative risk assessment of fumonisins through the Daily intake (EDI) and Hazard Quotient (HQ) by point assessment method. Corn and its products were multiple polluted by FBs, and the pollution degree of corn flour and corn-based cake were higher than that of corn kernels. The food exposure risk of FBs in 2-6 years old was higher than that of standard population, urban standard population and rural standard population. The exposure risk of fumonisins in high consumption group was higher than that in general consumption group. The food exposure risk of corn with average content of fumonisins was basically at an acceptable level, but corn and its products with high FBs content caused greater risk for children aged 2-6 years old and adults with high corn consumption.
Downloads
Referências
Alizadeh, A.M., Roshandel, G., Roudbarmohammadi, S., Roudbary, M., Sohanaki, H., Ghiasian, S.A., Taherkhani, A., Semnani, S., Aghasi, M. (2012). Fumonisin B1 contamination of cereals and risk of esophageal cancer in a high risk area in northeastern Iran. Asian Pac. J. Cancer Prev., 13, 2625-2628. DOI: 10.7314/apjcp.2012.13.6.2625.
Assuncao R., Vasco E., Nunes B., Loureiro S., Martins C., Alvito P. (2015). Single-compound and cumulative risk assessment of mycotoxins present in breakfast cereals consumed by children from Lisbon region, Portugal.Food and Chemical Toxicology, 86, 274-281. http://dx.doi.org/10.1016/j.fct.2015.10.017.
Bryła, M., Roszko, M., Szymczyk, K., Jędrzejczak, R., Obiedziński, M. W., Sękul, J. (2013). Fumonisins in plant-origin food and fodder—a review. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(9),1626-1640. DOI:10.1080/19440049.2013.809624.
Burger, H.M., Lombard, M.J., Shephard, G.S., Rheeder, J.R., Westhuizen, L.V.D., Gelderblom, W.C.A. (2010). Dietary fumonisin exposure in a rural population of South Africa. Food & Chemical Toxicology, 48(8-9):2103-2108.https://doi.org/10.1016/j.fct.2010.05.011.
Cendoya, E., Chiotta, M. L., Zachetti, V., Chulze, S. N., & Ramirez, M. L. (2018). Fumonisins and fumonisin-producing fusarium occurrence in wheat and wheat by products: a review. Journal of Cereal Science, 80:158-166.https://doi.org/10.1016/j.jcs.2018.02.010.
Chen, J., Wei, Z., Wang, Y., Long, M., Kuca, K. (2021). Fumonisin B1: mechanisms of toxicity and biological detoxification progress in animals. Food and Chemical Toxicology, 149(3), 111977.https://doi.org/10.1016/j.fct.2021.111977.
Claeys L., Romano C., Ruyck K.D., Wilson H., Huybrechts I. (2020). Mycotoxin exposure and human cancer risk: a systematic review of epidemiological studies. Science and Food Safety, 19(4): 1449-1464. DOI: 10.1111/1541-4337.12567.
Coppa, C., Khaneghah, A. M., Alvito, P., Assuno, R., & Oliveira, C. (2019). The occurrence of mycotoxins in breast milk, fruit products and cereal-based infant formula: a review. Trends in Food Science & Technology,92,81-93. https://doi.org/10.1016/j.tifs.2019.08.014.
Dall’Asta, C., Battilani, P. (2016). Fumonisins and their modified forms, a matter of concern in future scenario? World Mycotoxin J. ,9, 727-739. https://doi.org/10.3920/WMJ2016.2058.
Damiani, T., Righetti, L., Suman, M.,Galaverna, G., Dall’Asta, C. (2019). Analytical issue related to fumonisins: A matter of sample comminution? Food Control,95, 1-5. https://doi.org/10.1016/j.foodcont.2018.07.029.
European Commission. Commission Regulation (EC)No 1881/2006, Setting maximum lenels for certain contamination in food stuffs. Official Journal of the European Union,2006, L364:15-18.
Eze, U.A., Routledge, M.N., Okonofua, F.E., Huntriss, J., Gong, Y.Y. (2018). Mycotoxin exposure and adverse reproductive health outcomes in Africa: a review. World Mycotoxin J., 11(3): 321-339. DOI: 10.3920/WMJ2017.2261.
Falavigna, C., Cirlini, M., Galaverna, G., Dall’Asta, C. (2012).Masked fumonisins in processed food: Co-occurrence of hidden and bound forms and their stability under digestive conditions. World Mycotoxin J., 5, 325-334. https://doi.org/10.3920/WMJ2012.1403.
FAO/WHO CODEX ALIMENTARIUS.CODEX STAN 193-1995(Amended in 2015), General standard for contaminants and toxins in food and feed.
Gong C.B., Dong F.G., Wang Z.X. (2018). Investigation and Analysis of Mycotoxins Contamination in Cereal and Its Products Sold in Yantai Market. Food Research And Development, 39(16):189-194. DOI:10.3969/j.issn.1005-6521.2018.16.036.
Guo, Y.D., Chen, L., Yuan, Y. H., Yue T.L. (2013). Dietary Exposure and Risk Assessment of Aflatoxin B1 in Corn-based Foods in China Using Probabilistic Approach. Food Science, 34(011):24-27. DOI: 10.7506/spkx1002-6630-201311006.
Gutema, T., Munimbazi, C., Bullerman, L.B. (2000). Occurrence of fumonisins and moniliformin in corn and corn-based food products of US origin. J. Food Prot., 63, 1732-1737. https://doi.org/10.4315/0362-028X-63.12.1732.
Harrison, L.R., Colvin, B.M., Greene, J.T., Newman, L.E., Cole Jr, J.R. (1990). Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Investig. ,2,217-221. https://doi.org/10.1177/104063879000200312.
Humpf, H.U., V oss, K.A. (2004). Effects of thermal food processing on the chemical structure and toxicity of fumonisin mycotoxins. Mol. Nutr. Food Res. ,48, 255-269. https://doi.org/10.1002/mnfr.200400033.
Jeimy, C.M., Luis, M., Andréia B (2021). Incidence of aflatoxins and fumonisins in grain, masa and corn tortillas in four municipalities in the department of Lempira, Honduras. Heliyon, 7, e08506. https://doi.org/10.1016/j.heliyon.2021.e08506.
Jones, C., Ciacci-Zanella, J.R., Zhang, Y., Henderson, G., Dickman, M. (2001). Analysis of fumonisin B1-induced apoptosis. Environ. Health Perspect, 109 (Suppl. 2), 315–320. http://dx.doi.org/10.1289/ehp.01109s2315.
Kacholi, D., Sahu M. Levels and health risk assessment of heavy metals in soil, water, and vegetables of Dares Salaam, Tanzania (2018). Journal of Chemistry, 1-10, https://doi.org/10.1155/2018/1402674.
Li, J.Z., Zhao, X.D., Wang, Y, Li, S., Qin, Y.K., Han, T., Gao, Z.X., Liu, H (2021). A highly sensitive immunofluorescence sensor based on bicolor upconversion and magnetic separation for simultaneous detection of fumonisin B1 and zearalenone. Analyst, 146(10): 3328-3335. DOI: 10.1039/d1an00004g.
Li, J.L., Wang, S.Z., Wu, J.W., Shen L., Yao X.J. (2020). Investigation of mycotoxins in grain and its products in Henan Province. Chinese J. Food Hygiene, 32(4):418-421.
Liverpool-Tasie, L., Turna, N.S., Ademola, O., Obadina, A., Wu, F. (2019).The occurrence and co-occurrence of aflatoxin and fumonisin along the maize value chain in southwest Nigeria. Food Chem. T oxicol., 129,458-465. https://doi.org/10.1016/j.fct.2019.05.008.
Martins, F.A., Ferreira, F.M.D.,Ferreira, F.D., Bando, É., Nerilo, S.B., Hirooka, E.Y ., Machinski J. M. (2012).Daily intake estimates of fumonisins in corn-based food products in the population of Parana, Brazil. Food Control, 26, 614-618. https://doi.org/10.1016/j.foodcont.2012.02.019.
Meng, F.L., Fan, H., Tan, L., Nowacka A., Song Z.F., Wei C.Y. (2021). Contamination Status and Dietary Risk Assessment of Corn Mycotoxins in Jilin Province. Journal of Maize Sciences, 29(5):88-94.
Odjo, S, Alakonya, A.E., Rosales-Nolasco, A., Molina, A.L., Muñoz, C., Palacios-Rojas, N. (2022). Occurrence and postharvest strategies to help mitigate aflatoxins and fumonisins in maize and their co-exposure to consumers in Mexico and Central America. Food Control, 138:108968. https://doi.org/10.1016/j.foodcont.2022.108968.
Petrarca, M.H., Rossi, E.A., CMD, S. (2016). In-house method validation, estimating measurement uncertainty and the occurrence of fumonisin B1 in samples of brazilian commercial rice. Food Control, 59, 439-446. https://doi.org/10.1016/j.foodcont.2015.06.004
Rheeder, J.P., Marasas, W.F., Vismer, H.F. (2002). Production of fumonisin analogs by Fusarium species. Appl. Environ. Microbiol. 68, 2101-2105. 10.1128/AEM.68.5.2101-2105-2002.
Ross, P .F.,Rice, L.G., Osweiler, G.D., Nelson, P .E., Richard, J.L., Wilson, T.M. (1992) A review and update of animal toxicoses associated with fumonisin-contaminated feeds and production of fumonisins by Fusarium isolates. Mycopathologia, 117, 109-114. http://dx.doi.org/10.1007/BF00497286.
Shen, G.H., Kang, X.C., Su, J.S., Qiu, J.B., Liu, X., Xu, J.H., Shi J.R., Mohamed, S.R. (2022). Rapid detection of fumonisin B1 and B2 in ground corn samples using smartphone-controlled portable near-infrared spectrometry and chemometrics. Food Chemistry, 384,132487. https://doi.org/10.1016/j.foodchem.2022.132487.
Solfrizzo, M., Chulze, S., Mallmann, C., Visconti, A., De Girolamo, A., Rojo, F., Torres, A. (2004). Comparison of urinary sphingolipids in human populations with high and low maize consumption as a possible biomarker of fumonisin dietary exposure. Food Addit. Contam., 21, 1090-1095.
Voss, K.A.; Plattner, R.D., Riley , R.T., Meredith, F.I., Norred, W.P . (1998). In vivo effects of fumonisin B1-producing and fumonisin B1-nonproducing Fusarium moniliforme isolates are similar: Fumonisins B2 and B3 cause hepato-and nephrotoxicity in rats. Mycopathologia, 141, 45-58. http://dx.doi.org/10.1023/A:1006810916344.
Wan, J., Chen, B., Rao, J. (2020). Occurrence and preventive strategies to control mycotoxins in cereal-based food. Compr. Rev. Food Sci. Food Saf.,19 (3), 928-953. https://doi.org/10.1016/j.fct.2021.112768.
Wang, X.Q., Wu, Y.N., Chen, J.S. (2002). Low level data processing of food contamination monitoring. Chinese Journal of Preventive Medicine,36(4):278-279. https://doi.org/10.3760/j:issn:0253-9624.2002.04.022.
WHO. (2021). Micotoxinas. https://www.who.int/es/news-room/fact-sheets/detail/mycotoxins.
Wokorach, G., Landschoot, S., Anena, J., Audenaert, K., Haesaert, G. (2021). Mycotoxin profile of staple grains in northern Uganda: Understanding the level of human exposure and potential risks. Food Control, 122, 107813. https://doi.org/10.1016/j.foodcont.2020.107813.
Yang, D.J., Li, N., (2013). National Working Manual on the Risk of Food Contamination and Hazardous Factors. Beijing: China Quality Inspection Press,2013,250-257.
Yu, S., He, L., Yu, F., Liu, L., Qu, C., Qu, L., Wu, Y. (2018). A lateral flow assay for simultaneous detection of Deoxynivalenol, Fumonisin B1 and Aflatoxin B1. Toxicon 156, 23-27. https://doi.org/10.1016/j.toxicon.2018.10.305.